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SGplus

SGPlus research profile and competence

 

Preclinical chronic models for outsourcing biomedical research

Total exocrine pancreatic insufficiency (EPI) model

For enzyme supplementation studies and studying of the exeocrine pancreas relation to growth.

 

Relationship between the endocrine and exocrine pancreatic function (pigs)

This subject was profoundly explored using chronic models of pancreas and duodenum

fistulation with parallel ganglion nodosus preparation and use of cold reversible blockage of the

vagus nerve in healthy and diabetic animals .

 

Regulation of the exocrine pancreas (rats, pigs)

This study led us to the exciting discovery, proven experimentally, that in pigs the CCK

dependent pancreatic enzyme secretion is regulated via short peptidergic reflexes originating in

the duodenum, and is switched on by CCK produced in the duodenum. The pig model developed

for this study incorporated several catheters implanted in different visceral arterial vessels

supplying separately the duodenum and/or pancreas which allowed delivery of the hormone

(CCK) independently to the duodenum, pancreas and peripheral circulation.

 

Animal growth and its relation to development of the pancreas and gut function (rats, pigs)

The research describing the relationship between pancreatic and gut function and development

around weaning was evaluated in several PhD-Thesis.

Animal models allowed to estimate the effects of pancreatic juice and gut mioelectrical migrating

complexes (MMC) on bacteria growth.

 

Induction of gut maturation (mice rats, pigs)

Studies on the dietary factors trigging precocious maturation of gut and other tissues have been

started for some years ago at Lund University on pig model using lectins and psncreatic like

enzymes as stimulators. Lectins enhance the expression of Na/ H+ exchangers in the gut and

cause activation of NFκB, which are a direct sign of maturation.

 

Macromolecule absorption from the gut and lungs (rats, pigs)

Studies were preformed on pigs. Gavages and areolisation models were developed. The efficacy

of gut vs. lungs for different drug and metabolic marker absorption in health and acute

inflammation were estimated.

 

Lymph visceral and thoracic duct flow (pigs, shep)

Study on cholesterol and drug absorption.

 

Bile secretion model (pigs)

Regulation of pancreatic secretion. Drug re-circulation e.g., DDVP, etc.

Local gut inflammation model (rats, pigs)

A chronic model for gut inflammation was developed via infusion of PHA to mesenteric artery.

 

Jugular, portal and hepatic veins, mesenteric artery catheterization (rats, pigs, sheep)

This technique has been mastered and perfected for acute and chronic continual and repeatable

pharmaco - dynamic and - kinetic experiments.

 

Visceral circulation (rats, pigs, sheep)

Absorption experiments and liver function experiments (perfusion in situ).

 

Hind limb circulation/perfusion (sheep, goats, pigs)

Studies on peptide and amino acids utilisation in muscle and skin metabolism.

 

Macromolecular absorption from nasal mucosa (pigs, rats)

Absorption of oxytocin analogues.

 

Nephrectomy (7/8) (rats,pigs)

Uremic models for testing nitrogen evacuation via kidney vs. gut.

 

Ovariectomy (rats)

Osteoporosis model.

 

Gastrectomy (pigs, rats)

Osteoporosis model

 

Perinatal physiology in pigs

Surgery on foetus at 100 day of gestation – macromolecule absorption, etc

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